The global calculations of high-resolution molecular spectra using the variational and the effective operator techniques have been analyzed comparatively. The main results on the global modeling of high-resolution spectra of CO2, N2O, C2H2, H2O, O3, and H2S molecules, obtained at the Laboratory of Theoretical Spectroscopy, IAO SB RAS in collaboration with colleagues from CNRS (France) and NASA (USA) are briefly presented.