The two-quantum standard method is applied to determine the efficiency of two-photon pumped fluorescence (TPPF) and the two-photon absorption (TPA) cross sections of high-efficiency red laser dyes, viz., dicyanomethylene-pyran derivatives in solutions and polymeric matrices. The highest TPA cross section for a Nd-YAG laser radiation (1064 nm) is observed in DCM-684 ethylacetate solution - 15.7 GM. The influence of the structure pyran derivatives and solvents on the change of TPA cross section and the TPPF efficiency is discussed.